Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study

Chang, Jiaming; Lin, Lei; Zhang, Wenli; Yang, Jiliang; Zhang, Mengzhen; Yin, Huimin; Zhang, Xinxin; Zhou, Chunlei; Zou, Yan; He, Jing

doi:10.1186/s40246-025-00767-0

Human Genomics

Table 2 Stratification analysis for the associations of TRMT10C gene polymorphisms with neuroblastoma risk in children from Jiangsu Province

From: Genetic variants of m¹A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study

Variables	rs4618204 (cases/controls)		AOR (95% CI) ^a	P^a	rs3762735 (cases/controls)		AOR (95% CI) ^a	P^a	Riks genotypes (cases/controls)		AOR (95% CI) ^a	P^a
Variables	CC	CT/TT	AOR (95% CI) ^a	P^a	CC	CG/GG	AOR (95% CI) ^a	P^a	0–2	3–5	AOR (95% CI) ^a	P^a
Age, month
≤ 18	58/52	80/87	0.82 (0.51–1.34)	0.432	102/107	36/32	1.19 (0.68–2.06)	0.547	93/102	45/37	1.34 (0.80–2.24)	0.275
> 18	108/110	155/224	0.70 (0.50–0.99)	0.040	182/255	81/79	1.44 (1.00-2.07)	0.051	166/245	97/89	1.61 (1.14–2.28)	0.007
Gender
Females	71/80	120/145	0.93 (0.62–1.39)	0.730	135/164	56/61	1.12 (0.73–1.71)	0.617	128/164	63/61	1.32 (0.87–2.02)	0.192
Males	95/82	115/166	0.60 (0.41–0.87)	0.008	149/198	61/50	1.62 (1.05–2.49)	0.028	131/183	79/65	1.70 (1.14–2.53)	0.009
Sites of origin
Adrenal gland	37/162	56/311	0.79 (0.50–1.25)	0.317	59/362	34/111	1.89 (1.18–3.04)	0.008	63/347	30/126	1.30 (0.81–2.11)	0.280
Retroperitoneal	72/162	94/311	0.68 (0.47–0.98)	0.037	121/362	45/111	1.21 (0.81–1.81)	0.359	104/347	62/126	1.64 (1.13–2.39)	0.010
Mediastinum	49/162	71/311	0.76 (0.50–1.14)	0.180	89/362	31/111	1.14 (0.72–1.81)	0.582	77/347	43/126	1.54 (1.01–2.35)	0.048
Others	6/162	12/311	1.05 (0.39–2.85)	0.924	12/362	6/111	1.60 (0.59–4.39)	0.359	13/347	5/126	1.06 (0.37–3.03)	0.918
Clinical stages
I + II + 4s	74/162	99/311	0.70 (0.49-1.00)	0.053	118/362	55/111	1.51 (1.02–2.22)	0.037	109/347	64/126	1.60 (1.10–2.32)	0.013
III + IV	66/162	97/311	0.76 (0.53–1.10)	0.141	113/362	50/111	1.47 (0.99–2.18)	0.058	105/347	58/126	1.53 (1.05–2.24)	0.029

AOR, adjusted odds ratio; CI, confidence interval
^a Adjusted for age and gender, omitting the correspondence factor
^b Risk genotypes were carriers with rs7641261 CC/CT, rs2303476 CC, rs4618204 CC, rs4257518 GG, and rs3762735 CG/GG genotypes

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