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Fig. 7 | Human Genomics

Fig. 7

From: BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma

Fig. 7

BAX expression and functional impact in ccrcc cells. (A) Expression difference of BAX in adjacent normal tissue and tumor tissue was analyzed in pairs. (B) Comparison of BAX mRNA levels in normal tubular epithelial cells (HK-2) and ccRCC cell lines. (C, D) qRT-PCR to validate BAX knockdown efficiencies in 786-O and 769-P cells (siBAX vs. siControl). (E, F) CCK-8 assay demonstrated that BAX silencing significantly inhibited the proliferation of 786-O and 769-P cells. (G, H) Colony formation assays showed that BAX knockdown decreased the clonogenesis ability of cells, and quantitative analysis was shown on the right

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Human Genomics

ISSN: 1479-7364