Table 2 Clinical characteristics of patients with STEMI according to the presence of CHIP mutations
Characteristics | Total | CHIP carriers | Non-carriers | p |
|---|---|---|---|---|
Number (n) | 101 | 37 | 64 | Â |
Age, y, mean ± SD [range] | 61 ± 11.4 [38–89] | 65.2 ± 10.9 [40–89] | 58.6 ± 11.1 [38–89] | 0.005 |
Gender (female), n (%) | 11 (10.9%) | 4(10.8%) | 7 (10.9%) |  > 0.999 |
Weight, kg, mean ± SD | 71.7 ± 11.3 | 68.6 ± 10.8 | 73.3 ± 11.4 | 0.054 |
Height, cm, mean ± SD | 163.8 ± 11.3 | 164.4 ± 6.8 | 163.5 ± 13.3 | 0.636 |
BMI, kg/m2, mean ± SD | 27.6 ± 13.3 | 25.4 ± 3.4 | 28.9 ± 16.4 | 0.113 |
Dyslipidemia, n (%) | 35 (34.7%) | 9 (24.3%) | 26 (40.6%) | 0.129 |
Systemic hypertension, n (%) | 55(54.5%) | 21 (56.8%) | 34 (53.1%) | 0.836 |
Diabetes mellitus, n (%) | 26 (25.7%) | 8 (21.6%) | 18 (28.1%) | 0.637 |
Current smoker, n (%) | 56 (55.4%) | 21 (56.8%) | 35 (54.7%) |  > 0.999 |
SBP, mm Hg, mean ± SD | 126.3 ± 25 | 123.2 ± 26.4 | 128 ± 24.1 | 0.358 |
Prior CABG, n (%) | 0 (0%) | 0 (0%) | 0 (0%) | NA |
Killip class on admissions, n (%) | Â | Â | Â | 0.436 |
 I | 73 (72.3%) | 25 (67.6%) | 48 (75%) |  |
 II | 10 (9.9%) | 4 (10.8%) | 6 (9.4%) |  |
 III | 10 (9.9%) | 3 (8.1%) | 7 (10.9%) |  |
 IV | 8 (7.9%) | 5 (13.5%) | 3 (4.7%) |  |
Infarct-related artery, n (%) | Â | Â | Â | 0.427 |
 LAD | 44 (43.6%) | 12 (32.4%) | 32 (50%) |  |
 RCA | 21 (20.8%) | 8 (21.6%) | 13 (20.3%) |  |
 LCX | 8 (7.9%) | 3 (8.1%) | 5 (7.8%) |  |
 LM | 1 (1%) | 1 (2.7%) | 0 (0%) |  |
 LAD + RCA | 12 (11.9%) | 5 (13.5%) | 7 (10.9%) |  |
 RCA + LCX | 7 (6.9%) | 3 (8.1%) | 4 (6.3%) |  |
 LAD + LCX | 8 (7.9%) | 5 (13.5%) | 3 (4.7%) |  |
Therapy after discharge, n (%) | ||||
 Aspirin | 95 (94.1%) | 44 (93.6%) | 51 (96.2%) |  > 0.999 |
 Statin | 84 (83.2%) | 40 (85.1%) | 44 (83%) | 0.589 |
 β-Blocker | 87 (86.1%) | 39 (83%) | 48 (90.6%) | 0.766 |
 ACE inhibitors or ARB | 75 (74.3%) | 33 (70.2%) | 42 (79.2%) | 0.156 |
Biochemistry analysis at admission | ||||
 BUN, mg/dL, mean ± SD | 19 ± 8.1 | 19.2 ± 9.2 | 18.8 ± 7.5 | 0.816 |
 Creatinine, mg/dL, mean ± SD | 1.1 ± 0.6 | 1.1 ± 0.4 | 1.1 ± 0.7 | 0.847 |
 Total cholesterol, mg/dL, mean ± SD | 168.6 ± 37.7 | 165.8 ± 35.9 | 170.3 ± 39.2 | 0.562 |
 Triglyceride, mg/dL, mean ± SD | 147 ± 75.9 | 152 ± 81 | 144.1 ± 73.3 | 0.627 |
 LDL, mg/dL, mean ± SD | 100.8 ± 34.5 | 100.5 ± 36.1 | 101 ± 33.8 | 0.941 |
 HDL, mg/dL, mean ± SD | 47.3 ± 39.4 | 45.1 ± 32 | 48.5 ± 43.4 | 0.647 |
 Uric acid, mg/dL, mean ± SD | 6.6 ± 1.7 | 6.8 ± 1.9 | 6.6 ± 1.6 | 0.48 |
 Fasting glucose, mg/dL, mean ± SD | 119.1 ± 45.2 | 120.3 ± 56.4 | 118.4 ± 38.2 | 0.857 |
 Peak troponin I, ug/dL, mean ± SD | 39.9 ± 186 | 28.2 ± 61.4 | 46.9 ± 231.4 | 0.552 |
 LVEF, n (%) | 52.9 ± 11.7 | 52 ± 12.6 | 53.4 ± 11.2 | 0.585 |