Fig. 7
From: Tapping natures rhythm: the role of season in mitochondrial function and genetics in the UK biobank
Genome-wide and transcriptome-wide association study results for displacement (overall mtDNA abundance). Top panel (above 0): Genome-wide association study (GWAS); Manhattan plot of 6,112,950 variants with minor allele frequency greater 1% and their association with displacement. Genes closest to the association results are indicated above the association peaks. Bottom panel (below 0): Transcriptome-wide association study (TWAS); Genes expression associated with displacement estimated with TWAS-fusion. Genes below Bonferroni corrected P-Value threshold are labelled excluding duplicate genes. The blue line denotes genome-wide significance (P < 5.00 × 10− 08, top panel) or transcriptome wide significance (P < 1.00 × 10− 06). In the GWAS analysis, the closest genes in annotated while in the TWAS the respective gene is indicated