Fig. 6

Proteome-wide association study on seasonal patterns of mitochondrial abundance. The correlation between proteins and seasonal patterns of mitochondrial abundance computed with linear regression, adjusted for lifestyle and blood cell markers as well as total cholesterol and the first three principal components computed from the protein data. Each dot represents the Z-Score of the effect on the respective aspect of the seasonal patterns. Positive values indicate that the protein is associated with increased values in the respective pattern, while negative values indicate the opposite. The horizontal dotted lines denote the Z-Scores corresponding to the Bonferroni corrected P-value threshold of 0.000015 (i.e., 0.05/ 2923 markers). Proteins with a Z-Score above 6 or below − 10 are shown in Panel B. A: Protein markers associated with mtDNA amplitude (difference between maximum and minim value). B: Protein markers Protein markers associated with mtDNA displacement (vertical shift in mtDNA abundance). C: Protein markers associated with mtDNA acrophase (horizontal shift across the year)