Fig. 5

The association between laboratory markers (labWAS) and seasonal pattern of mitochondrial abundance. The association between metabolomic and other blood markers with seasonal mtDNA abundance patterns is shown as a manhattan plot. For each metabolite, we computed a linear regression model with mtDNA abundance as the outcome and modelled the interaction between that marker and the seasonal pattern to extract their effect on amplitude, acrophase and displacement. The analyses were adjusted for lifestyle and immune markers and additionally for total cholesterol to reduce the impact of cholesterol measurement in the results. The horizontal dotted lines denote the Z-Scores corresponding to the Bonferroni corrected P-value threshold of 0.0001 (i.e., 0.05/379 markers). Dots represent the effects observed on displacement, X the effects observed on acrophase and the diamond the effects on the amplitude