Fig. 4

Postprandial contributions of cells and tissues to cfDNA inferred from the fragmentation index. The correlation between the fragmentation index of 16,158 gene body regions and the average expression of these genes in 65 cells (A) and 51 tissue (B) types from the Human Protein Atlas (HPA) database were ranked. (C) Ranking of correlations for 18 immune cell types. Violin plots show the distribution of medians (black dots) and quartiles (dotted lines). Cell types with increased (red) or decreased (blue) relative contribution to cfDNA 30 min after a meal (D) and 2 h after a meal (E). Tissue types with increased (red) or decreased (blue) relative contribution to cfDNA 30 min after a meal (F) and 2 h after a meal (G). 95% confidence intervals (CI) for sorting differences were estimated using 10,000 bootstrap replicates