Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma

Table 6 Mediation analysis results using SEM

Path	Estimate	SE	P
DAG (A)-1
IOP \(\:\to\:\) CH (a)	-0.101	0.007	< 0.001
CH \(\:\to\:\) POAG (b)	-0.360	0.044	< 0.001
IOP \(\:\to\:\) POAG (c)	-0.178	0.020	< 0.001
IOP \(\:\to\:\) CH \(\:\to\:\) POAG (a*b)	0.036	0.005	< 0.001
DAG (A)-2
MOPP \(\:\to\:\) CH (a)	0.023	0.001	< 0.001
CH \(\:\to\:\) POAG (b)	-0.002	0.000	< 0.001
MOPP \(\:\to\:\) POAG (c)	-0.002	0.000	< 0.001
MOPP \(\:\to\:\) CH \(\:\to\:\) POAG (a*b)	-0.001	0.000	< 0.001
DAG (B)-1
IOP \(\:\to\:\) RE (d)	-0.042	0.002	< 0.001
RE\(\:\:\to\:\) POAG (e)	-0.002	0.000	< 0.001
IOP \(\:\to\:\) POAG (f)	0.006	0.000	< 0.001
IOP \(\:\to\:\) RE \(\:\to\:\) POAG (d*e)	0.000	0.000	< 0.001
DAG (B)-2
MOPP \(\:\to\:\) RE (d)	0.010	0.001	< 0.001
RE \(\:\to\:\) POAG (e)	-0.003	0.000	< 0.001
MOPP \(\:\to\:\) POAG (f)	-0.002	0.000	< 0.001
MOPP \(\:\to\:\) RE \(\:\to\:\) POAG (d*e)	-0.001	0.000	< 0.001

CH, corneal hysteresis; DAG, directed acyclic graphs; IOP, intraocular pressure; RE, refractive error; SE, standard error; MOPP, mean ocular perfusion pressure; POAG, primary open-angle glaucoma; P, p-value from SEM; SEM, structural equation models

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