Fig. 2
From: Genetic risk factors associated with ocular perfusion pressure in primary open-angle glaucoma
Directed acyclic graphs (DAG) for mediation analysis. Path diagram for mediation analysis model with mediators. DAG (A) depicts a model where IOP or MOPP are the exposures, CH is the mediator, and POAG is the outcome. DAG (B) illustrates a model where IOP or MOPP are the exposures, RE is the mediator, and POAG is the outcome. For the sake of simplicity, the confounders (age and sex) are not shown. The estimates corresponding to (a) through (f) are shown in Table 6. CH, corneal hysteresis; CRF, corneal resistance factor; IOP, intraocular pressure; RE, refractive error, MOPP, mean ocular perfusion pressure; POAG, Primary open-angle glaucoma