Fig. 4

Intra-syndrome facial phenotype similarity. A bar plot presenting intra-group cosine similarity between facial phenotype descriptors for histone-related syndromes, including sample size information (n). Darker green values correspond to larger sample sizes. Top 10 syndromes with the highest intra-group similarity: IDDAM, Stolerman, Bryant, IDDSSAD, Rahman, NEDSID, Snijders, CHARGE, Kleefstra, and Wiedemann. (ArboledA: Arboleda–Tham syndrome; ATRX: Alpha-thalassemia/impaired intellectual development syndrome; BIS: Blepharophimosis- impaired intellectual development syndrome; Bryant: Bryant–Li–Bhoj neurodevelopmental syndrome; Claes: Claes–Jensen syndrome; Coffin: Coffin–Siris syndrome; Cornelia: Cornelia De Lange syndrome; Diets: Diets–Jongmans syndrome; DYT: Childhood-onset dystonia 28; Floating: Floating-Harbor syndrome; HH5: Hypogonadotropic hypogonadism 5 with or without anosmia; IDDAM: Intellectual development disorder with autism and macrocephaly; IDDSELD: Intellectual development disorder with seizures and language delay; IDDSSAD: Intellectual developmental disorder with severe speech and ambulation defects; Luscan: Luscan Lumish syndrome; Menke: Menke–Hennekam syndrome; NEDSID: Neurodevelopmental disorder with speech impairment and dysmorphic facies; Rauch: Rauch–Steindl syndrome; Rubinstein: Rubinstein–Taybi syndrome; Say: Barber Say syndrome; Siderius: Siderius X-linked intellectual developmental disorder; Sifrim: Sifrim–Hitz-Weiss syndrome; Snijders: Snijders Blok–Campeau syndrome; Stolerman: Stolerman neurodevelopmental syndrome; Suleiman: Suleiman–El-Hattab syndrome; Tessadori: Tessadori-Van Haaften neurodevelopmental syndrome; Wiedemann: Wiedemann–Steiner syndrome)