Fig. 6

The figure shows the signal transduction network and drug-gene interaction network. a, b shows the four signal transduction paths of the four TRFs toward TTF1 gene in the upper part and FOXO1 gene in the lower part. The blue line in the network represents positive regulation, and the red-colored edges represent negative regulation of the target node. In c the drugs targeting lifestyle-based and disease genes are shown. Drug nodes are colored as follows: purple, dark blue, and faint yellow for drugs targeting MDD, PTSD hubs, and TRFs (MYC, GATA2, TCF4), respectively. In contrast, the gene source nodes are green