Table 1 Locus reported for AVB and LBBB in the meta-analysis of UK Biobank and FinnGene GWAS datasets
From: Genetic insights into cardiac conduction disorders from genome-wide association studies
SNP | CHR | POS | EA | NEA | EAF | N | BETA | SE | p value | Nearest gene | Consequence | PhyloP score | CADD scaled score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AVB | |||||||||||||
 rs185591978 | 2 | 178,488,129 | A | G | 0.94 | 349,625 | − 0.03 | 0.005 | 2.60 × 10−9 | PLEKHA3 | intron | − 0.096 | 2.01 |
 rs13031826 | 2 | 178,891,875 | A | T | 0.88 | 732,669 | − 0.02 | 0.003 | 1.19 × 10−12 | TTN | intron | 0.166 | 1.314 |
 rs10936712 | 3 | 172,084,486 | T | C | 0.69 | 349,625 | − 0.01 | 0.003 | 1.48 × 10−8 | FNDC3B | intron | − 1.75 | 0.353 |
 rs56065557 | 3 | 185,636,428 | C | G | 0.70 | 732,669 | − 0.01 | 0.002 | 8.35 × 10−9 | SENP2 | intergenic | − 1.28 | 0.382 |
 rs7433306 | 3 | 38,729,148 | C | G | 0.57 | 732,669 | 0.01 | 0.002 | 1.45 × 10−10 | SCN10A | intron | − 0.547 | 0.482 |
 rs199561133 | 4 | 110,760,807 | T | G | 0.86 | 349,625 | − 0.02 | 0.003 | 2.59 × 10−8 | RRH | intergenic | 0.056 | 4.358 |
 rs2932971 | 4 | 23,817,261 | T | C | 0.71 | 732,669 | 0.01 | 0.002 | 1.89 × 10−10 | PPARGC1A | intron | 5.0 | 19.45 |
 rs76734697 | 5 | 137,897,780 | T | G | 0.81 | 732,669 | 0.01 | 0.002 | 2.73 × 10−9 | PKD2L2 | intron | − 1.64 | 0.261 |
 rs6556061 | 5 | 173,218,944 | A | T | 0.72 | 349,625 | − 0.02 | 0.003 | 2.62 × 10−9 | NKX2-5 | intergenic | − 2.68 | 0.103 |
 rs11764098 | 7 | 35,466,100 | C | G | 0.97 | 732,669 | − 0.04 | 0.005 | 2.52 × 10−13 | TBX20 | intergenic | 2.27 | 18.17 |
LBBB | |||||||||||||
 rs1472095 | 4 | 23,816,454 | T | C | 0.71 | 727,785 | 0.010 | 0.002 | 3.35 × 10−8 | PPARGC1A | intron | − 0.718 | 0.789 |
 rs13185595 | 5 | 154,492,610 | A | G | 0.63 | 727,785 | − 0.012 | 0.002 | 5.55 × 10−13 | HAND1 | intergenic | − 0.514 | 4.449 |
 rs61931006 | 12 | 114,414,703 | A | C | 0.90 | 727,785 | 0.018 | 0.003 | 4.10 × 10−11 | TBX5 | intergenic | − 1.11 | 0.872 |
 rs9636578 | 21 | 27,538,384 | A | G | 0.52 | 727,785 | − 0.009 | 0.002 | 4.02 × 10−8 | ADAMTS5 | intergenic | 0.429 | 3.936 |