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Table 3 Baseline characteristics for patients in six different groups

From: Genetic landscape and ocular biometric correlations in microspherophakia: insights from a comprehensive patient cohort

 

FBN1

CBS

ADAMTS17

ADAMTSL4

LTBP2

ASPH

P

Patients

       

 Number, n (%)

31

5

5

3

4

2

-

 Sex (female/male)

14: 17

3: 2

5: 0

2: 1

2: 2

0: 2

0.955

 Age, years

12.76 ± 14.64

9.40 ± 7.23

44.20 ± 12.16

13.67 ± 11.26

12.00 ± 7.00

5

< 0.001

 Glaucoma, n (%)

1 (3.2%)

0 (0.0%)

1 (20.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0.968

Eyes

       

 IOP, n (%)

13.52 ± 5.95

13.20 ± 2.53

20.70 ± 7.03

16.50 ± 1.87

19.14 ± 5.82

13.50 ± 1.73

< 0.001

  < 10

9 (90.0%)

1 (10.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0.044

  10, 21

45 (58.4%)

9 (11.7%)

8 (10.4%)

6 (7.8%)

5 (6.5%)

4 (5.2%)

  > 21

4 (50.0%)

0 (0.0%)

2 (25.0%)

0 (0.0%)

2 (25.0%)

0 (0.0%)

 AL (mm)

25.63 ± 3.03

24.13 ± 3.25

23.79 ± 2.15

24.04 ± 2.51

24.15 ± 2.70

20.94 ± 0.54

0.011

 Z-AL

3.11 ± 3.32

1.25 ± 2.52

-0.72 ± 2.40

0.50 ± 1.70

0.85 ± 2.06

-2.02 ± 0.79

< 0.001

 WTW (mm)

12.18 ± 0.58

12.07 ± 0.16

11.7 ± 0.61

12.18 ± 0.25

12.78 ± 0.74

12.58 ± 0.61

0.009

 Z-WTW

0.53 ± 1.51

0.39 ± 0.89

-0.76 ± 1.52

0.30 ± 0.77

2.26 ± 1.70

1.51 ± 1.60

0.012

 Km (D)

39.91 ± 1.98

41.1 ± 0.61

44.44 ± 1.13

44.80 ± 1.54

43.34 ± 0.91

43.83 ± 0.34

< 0.001

 AST (D)

1.64 ± 1.39

2.97 ± 2.19

2.51 ± 2.01

3.06 ± 0.15

1.90 ± 1.14

2.48 ± 1.11

0.021

 CCT (µm)

518 ± 42

568 ± 71

534 ± 45

551 ± 33

547 ± 83

480 ± 11

0.122

 ACD (mm)

3.09 ± 0.83

2.75 ± 0.57

2.52 ± 0.31

2.79 ± 0.29

2.96 ± 0.81

1.64 ± 0.14

0.003

 LT (mm)

4.51 ± 1.120

4.72 ± 0.39

5.45 ± 0.40

4.17 ± 0.80

4.52 ± 0.46

4.46 ± 0.09

0.012

 Central ECC (cells/mm2)

3141 ± 511

2983 ± 449

2564 ± 270

3128 ± 178

2847 ± 247

2714 ± 17

0.005

  1. ACD = anterior chamber depth; AL = axial length; AST = corneal astigmatism; CCT = central corneal thickness; ECC = endothelial cell count; Km = mean keratometry; LT = lens thickness; WTW = white-to-white measurement