Fig. 3

The forest plot illustrated the MR analysis results based on 35 SAS-related SNPs (A) and after excluding 4 SNPs causing heterogeneity (B). The correlation of SNPs in both diseases was shown (C). The forest plot displayed the individual effects of each SNP (D). The funnel plot demonstrated the inverse variance weighted MR estimate for each SAS SNP with GERD versus 1/standard error (1/SEIV) (E)