Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development

Wu, Jian; Yang, Zitong; Ding, Jiafeng; Hao, Sida; Chen, Hong; Jin, Ke; Zhang, Cheng; Zheng, Xiangyi

doi:10.1186/s40246-025-00724-x

Human Genomics

Table 2 Detailed information of cis-pQTLs used as proxies of significant plasma protein levels and their causal effects on the risk of prostate cancer in PRACTICAL and FinnGen corhorts

From: Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development

Exposure	SNP	Effect allele	Other allele	Chr	Pos	Exposures			Prostate cancer (PRACTICAL)			Prostate cancer (FinnGen)
Exposure	SNP	Effect allele	Other allele	Chr	Pos	beta	se	pval	beta	se	pval	beta	se	pval
CREB3L4	rs6724	C	G	1	153,932,212	0.302	0.018	1.44E−62	0.061	0.009	1.18E−12	0.086	0.016	4.43E−08
HDGF	rs12121617	A	C	1	156,685,732	− 0.733	0.024	1.00E−200	− 0.033	0.009	1.22E−04	− 0.063	0.016	7.06E−05
HDGF	rs12145743	G	T	1	156,711,623	− 0.628	0.021	1.00E−200	− 0.034	0.009	5.32E−05	NA	NA	NA
SERPINA3	rs10149025	G	A	14	95,061,036	− 0.147	0.027	4.96E−08	− 0.041	0.014	0.003	− 0.009	0.023	0.682
SERPINA3	rs111397271	A	G	14	95,078,227	− 0.450	0.076	3.6E−09	− 0.105	0.040	0.008	− 0.047	0.051	0.350
SERPINA3	rs1884083	C	T	14	95,104,565	− 0.207	0.029	5.24E−13	− 0.015	0.014	0.281	0.002	0.025	0.950
SERPINA3	rs1955658	A	G	14	95,072,701	0.111	0.018	4.85E−10	0.022	0.009	0.015	0.016	0.017	0.333
SERPINA3	rs4905225	T	C	14	95,078,132	0.134	0.017	3.13E−15	0.009	0.009	0.334	0.008	0.016	0.593
SERPINA3	rs56361564	C	G	14	95,094,014	− 0.263	0.021	2.99E−35	− 0.039	0.011	5.42E−04	− 0.061	0.022	0.004
SERPINA3	rs8008044	C	G	14	95,149,668	− 0.453	0.046	2.65E−23	− 0.045	0.024	0.060	− 0.020	0.044	0.644
GNPNAT1	rs2296494	C	G	14	53,250,293	− 0.327	0.017	1.88E−82	0.401	− 0.034	0.008	0.482	− 0.025	0.015
TNFRSF6B	rs8957	G	T	20	62,373,707	0.152	0.019	4.01E−16	− 0.083	0.009	3.03E−19	− 0.039	0.018	0.026
GSK3A	rs61088131	C	T	19	42,700,947	0.125	0.023	4.59E−08	− 0.062	0.011	8.82E−09	− 0.013	0.025	0.602
EIF4B	rs146008363	A	T	12	53,431,298	− 0.212	0.036	3.19E−09	0.075	0.017	8.75E−06	0.076	0.024	0.001
SMAD2	rs11874858	A	G	18	45,457,818	0.135	0.017	6.69E−16	− 0.035	0.008	1.41E−05	− 0.063	0.015	2.65E−05
CLIC1	rs1265947	T	C	6	31,819,390	0.183	0.027	1.59E−11	− 0.055	0.013	1.99E−05	− 0.046	0.026	0.077

pQTL protein quantitative trait loci, SNP single nucleotide polymorphism

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ISSN: 1479-7364

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