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Fig. 1 | Human Genomics

Fig. 1

From: Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies

Fig. 1

Drivers of toxicokinetic (TK) variability. Physiological drivers include factors such as blood flows. Genetic factors include polymorphisms in enzymes such as CYP2D6, which results in varying rates of compound metabolism by poor metabolizers (P M), intermediate metabolizers (IM), extensive metabolizers (EM), and ultrarapid metabolizers (UM). Ontogenetic factors include changes in CYP expression over the course of pre and postnatal development. Adapted from “Fig. 1: Key life stages” from “Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age,” by EFSA Scientific Committee, used under CC BY-ND 4.0 [20]. Exposomic drivers include diet, lifestyle, environmental justice, and exposure/co-exposures

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Human Genomics

ISSN: 1479-7364