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Fig. 2 | Human Genomics

Fig. 2

From: The T-cell repertoire of Spanish patients with COVID-19 as a strategy to link T-cell characteristics to the severity of the disease

Fig. 2

Main results of the analyses using genes. For allele selection we excluded those clonotypes with ambiguous TRBV and TRBJ annotation. (A) V alleles with significant differences in frequency between mild and severe patients and (B) patients younger and older than 55 years. (C). Significative TRBV frequencies between the combined age and severity group. The allele frequency is calculated by weighting the degree of clonal expansion of the clonotype in which it is found. (D) Heatmap with hierarchical clustering of the total number of patients with the total number of V alleles and (E) J alleles detected. The expression levels in both heatmaps have been represented by z-score standardization of the total counts for each allele. Mann-Whitney U test was performed for two-group comparisons and one-way Kruskal-Wallis test for 4-group comparisons, plus post-hoc comparisons by Dunn’s test and corrected by the Bonferroni-Holm method (significance level of 0.05)

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Human Genomics

ISSN: 1479-7364