Fig. 1

Main results in α-diversity and clonality analyses for the combined age and severity group. (A) CHAO1 richness estimator, normalized Shannon-Wiener α-diversity indices and Gini-Simpson index, DE50 clonality index and Gini coefficient of inequality for patient groups. (B) Differences in the proportion of hyperexpanded, large, medium, small and rare clones. Classification of clones from their clonal expansion is based on the frequency intervals of a clonotype in a repertoire: Rare (0-1e-5), Small (1e-5-1e-4), Medium (1e-4-0.001), Large (0.001–0.01), Hyperexpanded (0.01-1). For comparisons of more than two groups, one-way Krsukal-Wallis test with Dunn’s test as posteriori test. For multiple post-hoc comparisons the p-value was corrected with the Bonferroni-Holm method. Significance level of 0.05