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Table 2 Associations of somatic variants in individual genes with clinical data

From: Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance

Characteristics

Wild type*

Mutant*

pcrude/padj

 

APC any variant

 

Stage I/II

18

25

0.036/0.075

Stage III/IV

8

32

 
 

APC frameshift variants

 

Stage I/II

36

7

0.015/0.056

Stage III/IV

23

17

 
 

TP53 any variant

 

Stage I/II

21

22

0.040/0.075

Stage III/IV

10

30

 
 

KRAS any variant

 

Stage I/II

29

14

0.048/0.080

Stage III/IV

18

22

 
 

KRAS-12D

 

Stage I/II

41

2

0.012/0.056

Stage III/IV

30

10

 
 

KRAS any variant

 

Grade 1

15

3

0.030/0.075

Grade 2

27

28

 

Grade 3

4

5

 
 

KRAS-12D

 

Grade 1

16

2

0.027/0.075

Grade 2

49

6

 

Grade 3

5

4

 
 

APC frameshift variants

 

Stable response

32

10

0.008/0.056

Progression

1

5

 
 

KRAS-12D

 

Stable response

38

4

0.005/0.056

Progression

2

4

 
  1. *Numbers of patients presented
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Human Genomics

ISSN: 1479-7364