Fig. 1

Study design overview. HMGCR, 3-hydroxy-3-methylglutaryl coenzyme A reductase; PCSK9, proprotein convertase subtilisin/kexin type 9; NPC1L1, Niemann-Pick C1-like 1; Chr, chromosome; LD, linkage disequilibrium; MAF, minor allele frequency; LDL-C, low-density lipoprotein cholesterol; GLGC, Global Lipids Genetics Consortium; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier