Fig. 5

Platelets are susceptible to accumulation of low-level heteroplasmic mtDNA mutations. Graphical representation of the mitochondrial genome with gene annotations. Red dots indicate locations with significantly different (p ≤ 0.001, t test) REA values in platelets of maternally associated ALS patients compared to unaffected controls a or compared to ALS patients without a maternal association of the disease b. bp Base pair