Fig. 1

Overview of integrative analysis workflow and narrow-sense heritability estimates. A Data generation and analysis workflow. B Overall distribution of the narrow-sense heritability (h2) for all features. C Composition of features by their h2 values across chemical classes. The h2 values are binned into five groups by 0.2. All features’ group (top) includes all 14,342 features. Only the identified metabolites are grouped under each of the 9 categories