Fig. 2
From: Differential upregulation of AU-rich element-containing mRNAs in COVID-19
ARE-containing mRNAs are preferentially upregulated in virus-infected MRC5 cell lines. A Fractions of ARE-containing mRNAs within the overexpressed and under-expressed groups of mRNAs in SARS-CoV-1- and MERC-CoV-infected MRC5 lung cells. Virus and cell lines are indicated. P value for difference in population proportion depicted as ****(P < 0.0001). B Log2 Fold Change of ARE- and non-ARE mRNA levels are displayed. Significantly differentially expressed mRNA (Padj < 0.05) were split into those that contain AREs and those that do not (non-ARE) and displayed as a dot plot with medians with interquartile ranges. The types of infecting viruses are depicted. Statistical significance was determined by Mann–Whitney t test in Graph prism and P value displayed in graph. C Volcano plots, Log 2 Fold of control against Log10 of adjusted P value of overexpressed ARE-mRNAs in selected different types of cells lines and infecting viruses. The dots of 20 most significantly differentially expressed mRNAs are colored in red and their names are depicted