Figure 1
From: Transient receptor potential (TRP) gene superfamily encoding cation channels
Domain structure of the TRP superfamily. Five Group 1 TRP (TRPN is not expressed in mammals) (a) and two Group 2 TRP subfamilies (b) are listed. All subfamilies contain a six-transmembrane domain unit with a cation-permeable pore between domains I and II. Four such units are assembled as a hetero-or homotetramer to form TRP channels. Domain indications: ankyrin repeats (A), coiled-coil domain (cc), protein kinase domain (TRPM6/7 only), cation-permeable pore ( p), transmembrane (TM) domain, cation-permeable (+ + +), TRP domain (TRPC, TRPM only), large extracellular loop between TM I and II (TRPP, TRPML only). Adapted from Venkatachalam and Montell [5].